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In brief, with respect to the children described in the preceding section, studies were undertaken of the mortality and morbidity from malignancies with onset before the age of 20 years, in relation to parental radiation exposure Yoshimoto et al. For this presentation, we will for this and subsequent indicators present only the results derived from fitting a linear dose-response model to the occurrence of the various indicators of radiation-related damage, these indicators being treated as binary-response variable i. In 1984, some 39 years after the birth of the first children conceived following the bombings, there were only three births to proximally exposed parents, and it was decided to close the cohorts, effective January 1985. In particular, we contrast this approach to that of the murine studies, where estimates derived from different inbred strains have been combined in various fashions m sufuni sex com obtain an average doubling dose see Lüning and Searle 1971. In the light of all these considerations concerning point mutations, we will suggest that in m sufuni sex com series at least 0. RERF Tech rep 14—79. The ultimate potential for phenotypic ill effects of some of these mutations is best documented by the extensive studies of the hemoglobin loci, with the demonstration that nucleotide substitutions may result in abnormal hemoglobins e.

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